Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

Modified mRNA cap analogs aid in the study of mRNA-related processes and may enable creation of novel therapeutic interventions. We report the synthesis and properties of 11 dinucleotide cap analogs bearing a single boranophosphate modification at either the α-, β- or γ-position of the 5′,5′-triphos...

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Bibliografiske detaljer
Main Authors: Kowalska, Joanna, Wypijewska del Nogal, Anna, Darzynkiewicz, Zbigniew M., Buck, Janina, Nicola, Corina, Kuhn, Andreas N., Lukaszewicz, Maciej, Zuberek, Joanna, Strenkowska, Malwina, Ziemniak, Marcin, Maciejczyk, Maciej, Bojarska, Elzbieta, Rhoads, Robert E., Darzynkiewicz, Edward, Sahin, Ugur, Jemielity, Jacek
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Synthetic Biology and Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176373/
https://ncbi.nlm.nih.gov/pubmed/25150148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku757
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