Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

Modified mRNA cap analogs aid in the study of mRNA-related processes and may enable creation of novel therapeutic interventions. We report the synthesis and properties of 11 dinucleotide cap analogs bearing a single boranophosphate modification at either the α-, β- or γ-position of the 5′,5′-triphos...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kowalska, Joanna, Wypijewska del Nogal, Anna, Darzynkiewicz, Zbigniew M., Buck, Janina, Nicola, Corina, Kuhn, Andreas N., Lukaszewicz, Maciej, Zuberek, Joanna, Strenkowska, Malwina, Ziemniak, Marcin, Maciejczyk, Maciej, Bojarska, Elzbieta, Rhoads, Robert E., Darzynkiewicz, Edward, Sahin, Ugur, Jemielity, Jacek
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2014
Pynciau:
Synthetic Biology and Chemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176373/
https://ncbi.nlm.nih.gov/pubmed/25150148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku757
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