Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS

Analogs of the mRNA cap are widely employed to study processes involved in mRNA metabolism as well as being useful in biotechnology and medicinal applications. Here we describe synthesis of six dinucleotide cap analogs bearing a single phosphorothioate modification at either the α, β, or γ position...

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Hauptverfasser: Kowalska, Joanna, Lewdorowicz, Magdalena, Zuberek, Joanna, Grudzien-Nogalska, Ewa, Bojarska, Elzbieta, Stepinski, Janusz, Rhoads, Robert E., Darzynkiewicz, Edward, Davis, Richard E., Jemielity, Jacek
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2390807/
https://ncbi.nlm.nih.gov/pubmed/18430890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.990208
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