Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS

Analogs of the mRNA cap are widely employed to study processes involved in mRNA metabolism as well as being useful in biotechnology and medicinal applications. Here we describe synthesis of six dinucleotide cap analogs bearing a single phosphorothioate modification at either the α, β, or γ position...

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Bibliographic Details
Main Authors: Kowalska, Joanna, Lewdorowicz, Magdalena, Zuberek, Joanna, Grudzien-Nogalska, Ewa, Bojarska, Elzbieta, Stepinski, Janusz, Rhoads, Robert E., Darzynkiewicz, Edward, Davis, Richard E., Jemielity, Jacek
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2390807/
https://ncbi.nlm.nih.gov/pubmed/18430890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.990208
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