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mRNA cap analogues substituted in the tetraphosphate chain with CX(2): identification of O-to-CCl(2) as the first bridging modification that confers resistance to decapping without impairing translation
Analogues of the mRNA 5′-cap are useful tools for studying mRNA translation and degradation, with emerging potential applications in novel therapeutic interventions including gene therapy. We report the synthesis of novel mono- and dinucleotide cap analogues containing dihalogenmethylenebisphosphona...
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| 出版年: | Nucleic Acids Res |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5587727/ https://ncbi.nlm.nih.gov/pubmed/28666355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx569 |
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