mRNA cap analogues substituted in the tetraphosphate chain with CX(2): identification of O-to-CCl(2) as the first bridging modification that confers resistance to decapping without impairing translation

Analogues of the mRNA 5′-cap are useful tools for studying mRNA translation and degradation, with emerging potential applications in novel therapeutic interventions including gene therapy. We report the synthesis of novel mono- and dinucleotide cap analogues containing dihalogenmethylenebisphosphona...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Rydzik, Anna M., Warminski, Marcin, Sikorski, Pawel J., Baranowski, Marek R., Walczak, Sylwia, Kowalska, Joanna, Zuberek, Joanna, Lukaszewicz, Maciej, Nowak, Elzbieta, W. Claridge, Timothy D., Darzynkiewicz, Edward, Nowotny, Marcin, Jemielity, Jacek
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587727/
https://ncbi.nlm.nih.gov/pubmed/28666355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx569
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