Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex

Dcp1/2 is the major eukaryotic RNA decapping complex, comprised of the enzyme Dcp2 and activator Dcp1, which removes the 5′ m(7)G cap from mRNA, committing the transcript to degradation. Dcp1/2 activity is crucial for RNA quality control and turnover, and deregulation of these processes may lead to...

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Vydáno v:RNA
Hlavní autoři: Ziemniak, Marcin, Mugridge, Jeffrey S., Kowalska, Joanna, Rhoads, Robert E., Gross, John D., Jemielity, Jacek
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4793208/
https://ncbi.nlm.nih.gov/pubmed/26826132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.055152.115
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