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Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex
Dcp1/2 is the major eukaryotic RNA decapping complex, comprised of the enzyme Dcp2 and activator Dcp1, which removes the 5′ m(7)G cap from mRNA, committing the transcript to degradation. Dcp1/2 activity is crucial for RNA quality control and turnover, and deregulation of these processes may lead to...
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| Pubblicato in: | RNA |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4793208/ https://ncbi.nlm.nih.gov/pubmed/26826132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.055152.115 |
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