mRNAs containing the histone 3′ stem–loop are degraded primarily by decapping mediated by oligouridylation of the 3′ end

Metazoan replication-dependent histone mRNAs are only present in S-phase, due partly to changes in their stability. These mRNAs end in a unique stem–loop (SL) that is required for both translation and cell-cycle regulation. Previous studies showed that histone mRNA degradation occurs through both 5′...

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Main Authors: Su, Wei, Slepenkov, Sergey V., Slevin, Michael K., Lyons, Shawn M., Ziemniak, Marcin, Kowalska, Joanna, Darzynkiewicz, Edward, Jemielity, Jacek, Marzluff, William F., Rhoads, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527721/
https://ncbi.nlm.nih.gov/pubmed/23188809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.034470.112
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