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Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells
Capped RNAs synthesized by in vitro transcription have found wide utility for studying mRNA function and metabolism and for producing proteins of interest. We characterize here a recently synthesized series of cap analogs with improved properties that contain a sulfur substitution for a nonbridging...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1986804/ https://ncbi.nlm.nih.gov/pubmed/17720878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.701307 |
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