Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect

[Image: see text] mRNA-based therapies and vaccines constitute a disruptive technology with the potential to revolutionize modern medicine. Chemically modified 5′ cap structures have provided access to mRNAs with superior translational properties that could benefit the currently flourishing mRNA fie...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Warminski, Marcin, Kowalska, Joanna, Nowak, Elzbieta, Kubacka, Dorota, Tibble, Ryan, Kasprzyk, Renata, Sikorski, Pawel J., Gross, John D., Nowotny, Marcin, Jemielity, Jacek
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2021
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901015/
https://ncbi.nlm.nih.gov/pubmed/33439620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00864
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