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Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice

Many therapeutic leads fail to advance clinically because of bioavailability, selectivity, and formulation problems. Molecular transporters can be used to address these problems. Molecular transporter conjugates of otherwise poorly soluble or poorly bioavailable drugs or probes exhibit excellent sol...

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Main Authors: Wender, Paul A., Goun, Elena A., Jones, Lisa R., Pillow, Thomas H., Rothbard, Jonathan B., Shinde, Rajesh, Contag, Christopher H.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1965515/
https://ncbi.nlm.nih.gov/pubmed/17563383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703919104
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