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Real-time analysis of uptake and bioactivatable cleavage of luciferin-transporter conjugates in transgenic reporter mice

Many therapeutic leads fail to advance clinically because of bioavailability, selectivity, and formulation problems. Molecular transporters can be used to address these problems. Molecular transporter conjugates of otherwise poorly soluble or poorly bioavailable drugs or probes exhibit excellent sol...

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Autores principales: Wender, Paul A., Goun, Elena A., Jones, Lisa R., Pillow, Thomas H., Rothbard, Jonathan B., Shinde, Rajesh, Contag, Christopher H.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1965515/
https://ncbi.nlm.nih.gov/pubmed/17563383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703919104
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