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Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters

Many cancer therapeutic agents elicit resistance that renders them ineffective and often produces cross-resistance to other drugs. One of the most common mechanisms of resistance involves P-glycoprotein (Pgp)-mediated drug efflux. To address this problem, new agents have been sought that are less pr...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dubikovskaya, Elena A., Thorne, Steve H., Pillow, Thomas H., Contag, Christopher H., Wender, Paul A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527877/
https://ncbi.nlm.nih.gov/pubmed/18713866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805374105
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