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Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters
Many cancer therapeutic agents elicit resistance that renders them ineffective and often produces cross-resistance to other drugs. One of the most common mechanisms of resistance involves P-glycoprotein (Pgp)-mediated drug efflux. To address this problem, new agents have been sought that are less pr...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2527877/ https://ncbi.nlm.nih.gov/pubmed/18713866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805374105 |
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