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Development of a high-throughput screen for soluble epoxide hydrolase inhibition

Mammalian soluble epoxide hydrolase (sEH) represents a highly promising new target for drug development. Chemical inhibition of this enzyme in animal models was shown to treat hypertension and vascular inflammation as well as related syndromes. Existing sEH inhibitors are relatively potent and speci...

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Bibliografische gegevens
Hoofdauteurs: Wolf, Nicola M., Morisseau, Christophe, Jones, Paul D., Hock, Bertold, Hammock, Bruce D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2006
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1964503/
https://ncbi.nlm.nih.gov/pubmed/16729954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2006.04.045
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