Normal cellular prion protein is a ligand of selectins: binding requires Le(X) but is inhibited by sLe(X)

The normal PrP(C) (cellular prion protein) contains sLe(X) [sialyl-Le(X) (Lewis X)] and Le(X). sLe(X) is a ligand of selectins. To examine whether PrP(C) is a ligand of selectins, we generated three human PrP(C)–Ig fusion proteins: one with Le(X), one with sLe(X), and the other with neither Le(X) no...

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Main Authors: Li, Chaoyang, Wong, Poki, Pan, Tao, Xiao, Fan, Yin, Shaoman, Chang, Binggong, Kang, Shin-Chung, Ironside, James, Sy, Man-Sun
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2007
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948967/
https://ncbi.nlm.nih.gov/pubmed/17497959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061857
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