Ligand activation of LXRβ reverses atherosclerosis and cellular cholesterol overload in mice lacking LXRα and apoE

Liver X receptors (LXRs) α and β are transcriptional regulators of cholesterol homeostasis and potential targets for the development of antiatherosclerosis drugs. However, the specific roles of individual LXR isotypes in atherosclerosis and the pharmacological effects of synthetic agonists remain un...

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Bibliografski detalji
Glavni autori: Bradley, Michelle N., Hong, Cynthia, Chen, Mingyi, Joseph, Sean B., Wilpitz, Damien C., Wang, Xuping, Lusis, Aldons J., Collins, Allan, Hseuh, Willa A., Collins, Jon L., Tangirala, Rajendra K., Tontonoz, Peter
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2007
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924496/
https://ncbi.nlm.nih.gov/pubmed/17657314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31909
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