Impaired Development of Atherosclerosis in Abcg1(−/−)Apoe(−/−) Mice; Identification of Specific Oxysterols that both Accumulate in Abcg1(−/−)Apoe(−/−) Tissues and Induce Apoptosis

OBJECTIVE: ABCG1 is highly expressed in macrophages and endothelial cells, two cell types that play important roles in the development of atherosclerosis. We generated Abcg1(−/−)Apoe(−/−) mice in order to understand the mechanism and cell types involved in changes in atherosclerosis following loss o...

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Main Authors: Tarling, Elizabeth J., Bojanic, Dragana D., Tangirala, Rajendra K., Wang, Xuping, Lovgren-Sandblom, Anita, Lusis, Aldons J., Bjorkhem, Ingemar, Edwards, Peter A.
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881948/
https://ncbi.nlm.nih.gov/pubmed/20299684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.205617
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