Ligand activation of LXRβ reverses atherosclerosis and cellular cholesterol overload in mice lacking LXRα and apoE

Liver X receptors (LXRs) α and β are transcriptional regulators of cholesterol homeostasis and potential targets for the development of antiatherosclerosis drugs. However, the specific roles of individual LXR isotypes in atherosclerosis and the pharmacological effects of synthetic agonists remain un...

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Main Authors: Bradley, Michelle N., Hong, Cynthia, Chen, Mingyi, Joseph, Sean B., Wilpitz, Damien C., Wang, Xuping, Lusis, Aldons J., Collins, Allan, Hseuh, Willa A., Collins, Jon L., Tangirala, Rajendra K., Tontonoz, Peter
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2007
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924496/
https://ncbi.nlm.nih.gov/pubmed/17657314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31909
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