LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice

The liver X receptor (LXR) signaling pathway is an important modulator of atherosclerosis, but the relative importance of the two LXRs in atheroprotection is incompletely understood. We show here that LXRα, the dominant LXR isotype expressed in liver, plays a particularly important role in whole-bod...

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Detalhes bibliográficos
Main Authors: Hong, Cynthia, Bradley, Michele N., Rong, Xin, Wang, Xuping, Wagner, Alan, Grijalva, Victor, Castellani, Lawrence W., Salazar, Jon, Realegeno, Susan, Boyadjian, Rima, Fogelman, Alan M., Van Lenten, Brian J., Reddy, Srinivasa T., Lusis, Aldons J., Tangirala, Rajendra K., Tontonoz, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351819/
https://ncbi.nlm.nih.gov/pubmed/22454476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M022061
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