LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice

The liver X receptor (LXR) signaling pathway is an important modulator of atherosclerosis, but the relative importance of the two LXRs in atheroprotection is incompletely understood. We show here that LXRα, the dominant LXR isotype expressed in liver, plays a particularly important role in whole-bod...

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Autors principals: Hong, Cynthia, Bradley, Michele N., Rong, Xin, Wang, Xuping, Wagner, Alan, Grijalva, Victor, Castellani, Lawrence W., Salazar, Jon, Realegeno, Susan, Boyadjian, Rima, Fogelman, Alan M., Van Lenten, Brian J., Reddy, Srinivasa T., Lusis, Aldons J., Tangirala, Rajendra K., Tontonoz, Peter
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2012
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351819/
https://ncbi.nlm.nih.gov/pubmed/22454476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M022061
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