LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice

The liver X receptor (LXR) signaling pathway is an important modulator of atherosclerosis, but the relative importance of the two LXRs in atheroprotection is incompletely understood. We show here that LXRα, the dominant LXR isotype expressed in liver, plays a particularly important role in whole-bod...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Hong, Cynthia, Bradley, Michele N., Rong, Xin, Wang, Xuping, Wagner, Alan, Grijalva, Victor, Castellani, Lawrence W., Salazar, Jon, Realegeno, Susan, Boyadjian, Rima, Fogelman, Alan M., Van Lenten, Brian J., Reddy, Srinivasa T., Lusis, Aldons J., Tangirala, Rajendra K., Tontonoz, Peter
Format: Artigo
Langue:Inglês
Publié: The American Society for Biochemistry and Molecular Biology 2012
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351819/
https://ncbi.nlm.nih.gov/pubmed/22454476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M022061
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