Ligand activation of LXRβ reverses atherosclerosis and cellular cholesterol overload in mice lacking LXRα and apoE

Liver X receptors (LXRs) α and β are transcriptional regulators of cholesterol homeostasis and potential targets for the development of antiatherosclerosis drugs. However, the specific roles of individual LXR isotypes in atherosclerosis and the pharmacological effects of synthetic agonists remain un...

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Detalhes bibliográficos
Main Authors: Bradley, Michelle N., Hong, Cynthia, Chen, Mingyi, Joseph, Sean B., Wilpitz, Damien C., Wang, Xuping, Lusis, Aldons J., Collins, Allan, Hseuh, Willa A., Collins, Jon L., Tangirala, Rajendra K., Tontonoz, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924496/
https://ncbi.nlm.nih.gov/pubmed/17657314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31909
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