Ligand activation of LXRβ reverses atherosclerosis and cellular cholesterol overload in mice lacking LXRα and apoE

Liver X receptors (LXRs) α and β are transcriptional regulators of cholesterol homeostasis and potential targets for the development of antiatherosclerosis drugs. However, the specific roles of individual LXR isotypes in atherosclerosis and the pharmacological effects of synthetic agonists remain un...

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Hlavní autoři: Bradley, Michelle N., Hong, Cynthia, Chen, Mingyi, Joseph, Sean B., Wilpitz, Damien C., Wang, Xuping, Lusis, Aldons J., Collins, Allan, Hseuh, Willa A., Collins, Jon L., Tangirala, Rajendra K., Tontonoz, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2007
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924496/
https://ncbi.nlm.nih.gov/pubmed/17657314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31909
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