Somatic hypermutation of immunoglobulin genes in human neonates

The antibody response in the young infant is limited in several ways; in particular, responses generally are of low affinity and restricted to IgM. This raises the question whether the affinity maturation process, consisting of somatic mutation of immunoglobulin genes coupled with selection of high-...

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Bibliografiske detaljer
Main Authors: RIDINGS, J, NICHOLSON, I C, GOLDSWORTHY, W, HASLAM, R, ROBERTON, D M, ZOLA, H
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 1997
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904651/
https://ncbi.nlm.nih.gov/pubmed/9158112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1997.3631264.x
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