Aging-Related Changes in the Nigrostriatal Dopamine System and the Response to MPTP in Nonhuman Primates: Diminished Compensatory Mechanisms as a Prelude to Parkinsonism

Aging is the most prominent risk factor for Parkinson’s disease. Yet, consensus of how advancing age may predispose the dopamine (DA) system to parkinsonism is lacking. Three age-ranges of female rhesus monkeys, 8–9, 15–17 and 21–31 years, received unilateral DA depletion with intracarotid 1-methyl-...

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Hlavní autoři: Collier, Timothy J., Lipton, Jack, Daley, Brian F., Palfi, Stephane, Chu, Yaping, Sortwell, Caryl, Bakay, Roy A.E., Sladek, John R., Kordower, Jeffrey H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899875/
https://ncbi.nlm.nih.gov/pubmed/17254792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2006.11.013
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