Aging-Related Changes in the Nigrostriatal Dopamine System and the Response to MPTP in Nonhuman Primates: Diminished Compensatory Mechanisms as a Prelude to Parkinsonism

Aging is the most prominent risk factor for Parkinson’s disease. Yet, consensus of how advancing age may predispose the dopamine (DA) system to parkinsonism is lacking. Three age-ranges of female rhesus monkeys, 8–9, 15–17 and 21–31 years, received unilateral DA depletion with intracarotid 1-methyl-...

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Bibliografiske detaljer
Main Authors: Collier, Timothy J., Lipton, Jack, Daley, Brian F., Palfi, Stephane, Chu, Yaping, Sortwell, Caryl, Bakay, Roy A.E., Sladek, John R., Kordower, Jeffrey H.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899875/
https://ncbi.nlm.nih.gov/pubmed/17254792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2006.11.013
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