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Knockdown of ACAT-1 Reduces Amyloidogenic Processing of APP

Previous studies have shown that acyl-coenzyme A:cholesterol acyl transferase (ACAT), an enzyme that controls cellular equilibrium between free cholesterol and cholesteryl esters, modulates proteolytic processing of APP in cell-based and animal models of Alzheimer’s disease. Here we report that ACAT...

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Détails bibliographiques
Auteurs principaux: Huttunen, Henri J., Greco, Christopher, Kovacs, Dora M.
Format: Artigo
Langue:Inglês
Publié: 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1896096/
https://ncbi.nlm.nih.gov/pubmed/17412327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.03.056
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