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Novel N-terminal Cleavage of APP Precludes Aβ Generation in ACAT-Defective AC29 Cells
A common pathogenic event that occurs in all forms of Alzheimer’s disease is the progressive accumulation of amyloid β-peptide (Aβ) in brain regions responsible for higher cognitive functions. Inhibition of acyl-coenzyme A: cholesterol acyltransferase (ACAT), which generates intracellular cholestery...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2721794/ https://ncbi.nlm.nih.gov/pubmed/18618086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-008-9088-0 |
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