RETROMER DISRUPTION PROMOTES AMYLOIDOGENIC APP PROCESSING

Retromer deficiency has been implicated in sporadic AD and animals deficient in retromer components exhibit pronounced neurodegeneration. Because retromer performs retrograde transport from the endosome to the Golgi apparatus and neuronal Aβ is found in late endosomal compartments, we speculated tha...

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Библиографические подробности
Главные авторы: Sullivan, Christopher P., Jay, Anthony, Stack, Edward, Pakaluk, Maria, Wadlinger, Erin, Fine, Richard E., Wells, John M., Morin, Peter J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114192/
https://ncbi.nlm.nih.gov/pubmed/21515373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2011.04.002
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