RETROMER DISRUPTION PROMOTES AMYLOIDOGENIC APP PROCESSING

Retromer deficiency has been implicated in sporadic AD and animals deficient in retromer components exhibit pronounced neurodegeneration. Because retromer performs retrograde transport from the endosome to the Golgi apparatus and neuronal Aβ is found in late endosomal compartments, we speculated tha...

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Detalhes bibliográficos
Main Authors: Sullivan, Christopher P., Jay, Anthony, Stack, Edward, Pakaluk, Maria, Wadlinger, Erin, Fine, Richard E., Wells, John M., Morin, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3114192/
https://ncbi.nlm.nih.gov/pubmed/21515373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2011.04.002
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