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Tyr(682) in the Intracellular Domain of APP Regulates Amyloidogenic APP Processing In Vivo
BACKGROUND: The pathogenesis of Alzheimer's disease is attributed to misfolding of Amyloid-β (Aβ) peptides. Aβ is generated during amyloidogenic processing of Aβ-precursor protein (APP). Another characteristic of the AD brain is increased phosphorylation of APP amino acid Tyr(682). Tyr(682) is...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2982846/ https://ncbi.nlm.nih.gov/pubmed/21103325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015503 |
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