Tyr(682) in the Intracellular Domain of APP Regulates Amyloidogenic APP Processing In Vivo

BACKGROUND: The pathogenesis of Alzheimer's disease is attributed to misfolding of Amyloid-β (Aβ) peptides. Aβ is generated during amyloidogenic processing of Aβ-precursor protein (APP). Another characteristic of the AD brain is increased phosphorylation of APP amino acid Tyr(682). Tyr(682) is...

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Hauptverfasser: Barbagallo, Alessia P. M., Weldon, Richard, Tamayev, Robert, Zhou, Dawang, Giliberto, Luca, Foreman, Oded, D'Adamio, Luciano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982846/
https://ncbi.nlm.nih.gov/pubmed/21103325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015503
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