Pharmacological chaperones stabilize retromer to limit APP processing

Retromer is a multiprotein complex that trafficks cargo out of endosomes. The neuronal retromer traffics the amyloid-precursor protein (APP) away from endosomes, a site where APP is cleaved into pathogenic fragments in Alzheimer’s disease. Here we determined whether pharmacological chaperones can en...

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Detalhes bibliográficos
Main Authors: Mecozzi, Vincent J, Berman, Diego E, Simoes, Sabrina, Vetanovetz, Chris, Awal, Mehraj R, Patel, Vivek M, Schneider, Remy T, Petsko, Gregory A, Ringe, Dagmar, Small, Scott A
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076047/
https://ncbi.nlm.nih.gov/pubmed/24747528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1508
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