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Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease
Type 2 diabetes (T2D) is a major risk factor for late-onset Alzheimer's disease (AD). A variety of metabolic changes related to T2D (e.g. hyperinsulinemia, hyperglycemia, and elevated branched-chain amino acids) have been proposed as mechanistic links, but the basis for this association remains...
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| Publicado no: | Neurobiol Dis |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4235335/ https://ncbi.nlm.nih.gov/pubmed/24440570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.12.017 |
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