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The effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability

Human lysosomal enzymes acid-β-glucosidase (GCase) and acid-α-galactosidase (α-Gal A) hydrolyze, respectively, the sphingolipids glucosyl- and globotriaosyl- ceramide, and mutations in these enzymes lead to the lipid metabolism disorders Gaucher and Fabry disease. We have investigated the structure...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Lieberman, Raquel L., D'aquino, J. Alejandro, Ringe, Dagmar, Petsko, Gregory A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2009
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699628/
https://ncbi.nlm.nih.gov/pubmed/19374450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9002265
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