Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors

Mast cells play a central role in inflammatory and immediate-type allergic reactions by secreting a variety of biologically active substances, including sphingosine-1 phosphate (S1P). Sphingosine kinase 1 (SphK1) and formation of S1P, which leads to transactivation of S1P receptors and their downstr...

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Main Authors: Jolly, Puneet S., Bektas, Meryem, Watterson, Kenneth R., Sankala, Heidi, Payne, Shawn G., Milstien, Sheldon, Spiegel, Sarah
格式: Artigo
語言:Inglês
出版: The American Society of Hematology 2005
主題:
Immunobiology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1894993/
https://ncbi.nlm.nih.gov/pubmed/15741218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-12-4686
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