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Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors
Mast cells play a central role in inflammatory and immediate-type allergic reactions by secreting a variety of biologically active substances, including sphingosine-1 phosphate (S1P). Sphingosine kinase 1 (SphK1) and formation of S1P, which leads to transactivation of S1P receptors and their downstr...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society of Hematology
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1894993/ https://ncbi.nlm.nih.gov/pubmed/15741218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-12-4686 |
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