Transactivation of Sphingosine-1–Phosphate Receptors by FcɛRI Triggering Is Required for Normal Mast Cell Degranulation and Chemotaxis

Mast cells secrete various substances that initiate and perpetuate allergic responses. Cross-linking of the high-affinity receptor for IgE (FcɛRI) in RBL-2H3 and bone marrow–derived mast cells activates sphingosine kinase (SphK), which leads to generation and secretion of the potent sphingolipid med...

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Hlavní autoři: Jolly, Puneet S., Bektas, Meryem, Olivera, Ana, Gonzalez-Espinosa, Claudia, Proia, Richard L., Rivera, Juan, Milstien, Sheldon, Spiegel, Sarah
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2004
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211871/
https://ncbi.nlm.nih.gov/pubmed/15067032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030680
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