Impaired degranulation but enhanced cytokine production after FcɛRI stimulation of diacylglycerol kinase ζ–deficient mast cells

Calcium and diacylglycerol are critical second messengers that together effect mast cell degranulation after allergen cross-linking of immunoglobulin (Ig)E-bound FcɛRI. Diacylglycerol kinase (DGK)ζ is a negative regulator of diacylglycerol-dependent signaling that acts by converting diacylglycerol t...

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Detalhes bibliográficos
Main Authors: Olenchock, Benjamin A., Guo, Rishu, Silverman, Michael A., Wu, Jennifer N., Carpenter, Jeffery H., Koretzky, Gary A., Zhong, Xiao-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118304/
https://ncbi.nlm.nih.gov/pubmed/16717114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052424
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