Impaired degranulation but enhanced cytokine production after FcɛRI stimulation of diacylglycerol kinase ζ–deficient mast cells

Calcium and diacylglycerol are critical second messengers that together effect mast cell degranulation after allergen cross-linking of immunoglobulin (Ig)E-bound FcɛRI. Diacylglycerol kinase (DGK)ζ is a negative regulator of diacylglycerol-dependent signaling that acts by converting diacylglycerol t...

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Hauptverfasser: Olenchock, Benjamin A., Guo, Rishu, Silverman, Michael A., Wu, Jennifer N., Carpenter, Jeffery H., Koretzky, Gary A., Zhong, Xiao-Ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2006
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118304/
https://ncbi.nlm.nih.gov/pubmed/16717114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052424
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