Lipocalin-type prostaglandin D synthase/β-trace is a major amyloid β-chaperone in human cerebrospinal fluid

The conformational change in amyloid β (Aβ) peptide from its monomeric form to aggregates is crucial in the pathogenesis of Alzheimer's disease (AD). In the healthy brain, some unidentified chaperones appear to prevent the aggregation of Aβ. Here we reported that lipocalin-type prostaglandin D...

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Detalhes bibliográficos
Main Authors: Kanekiyo, Takahisa, Ban, Tadato, Aritake, Kosuke, Huang, Zhi-Li, Qu, Wei-Min, Okazaki, Issay, Mohri, Ikuko, Murayama, Shigeo, Ozono, Keiichi, Taniike, Masako, Goto, Yuji, Urade, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851035/
https://ncbi.nlm.nih.gov/pubmed/17404210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701585104
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