Lipocalin-type prostaglandin D synthase/β-trace is a major amyloid β-chaperone in human cerebrospinal fluid

The conformational change in amyloid β (Aβ) peptide from its monomeric form to aggregates is crucial in the pathogenesis of Alzheimer's disease (AD). In the healthy brain, some unidentified chaperones appear to prevent the aggregation of Aβ. Here we reported that lipocalin-type prostaglandin D...

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Hlavní autoři: Kanekiyo, Takahisa, Ban, Tadato, Aritake, Kosuke, Huang, Zhi-Li, Qu, Wei-Min, Okazaki, Issay, Mohri, Ikuko, Murayama, Shigeo, Ozono, Keiichi, Taniike, Masako, Goto, Yuji, Urade, Yoshihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851035/
https://ncbi.nlm.nih.gov/pubmed/17404210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701585104
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