Anti-inflammatory therapy by ibudilast, a phosphodiesterase inhibitor, in demyelination of twitcher, a genetic demyelination model

BACKGROUND: Twitcher mouse (twi/twi) is an authentic murine model of Krabbe's disease. Accumulation of psychosine, resulting in apoptosis of oligodendrocytes and subsequent demyelination, is a cardinal event to the pathogenesis of this disease. Moreover, recruitment of inflammatory cells plays...

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Main Authors: Kagitani-Shimono, Kuriko, Mohri, Ikuko, Fujitani, Yasushi, Suzuki, Kinuko, Ozono, Keiichi, Urade, Yoshihiro, Taniike, Masako
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2005
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1112612/
https://ncbi.nlm.nih.gov/pubmed/15813970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-2-10
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