Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons

Deposition of amyloid β-peptide (Aβ) in cerebral vessel walls (cerebral amyloid angiopathy, CAA) is very frequent in Alzheimer’s disease and occurs also as a sporadic disorder. Here, we describe significant CAA in addition to amyloid plaques, in aging APP/Ld transgenic mice overexpressing the London...

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Detalhes bibliográficos
Main Authors: Van Dorpe, Jo, Smeijers, Liesbet, Dewachter, Ilse, Nuyens, Dieter, Spittaels, Kurt, Van den Haute, Chris, Mercken, Marc, Moechars, Dieder, Laenen, Isabelle, Kuiperi, Cuno, Bruynseels, Koen, Tesseur, Ina, Loos, Ruth, Vanderstichele, Hugo, Checler, Frédéric, Sciot, Raf, Van Leuven, Fred
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2000
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850171/
https://ncbi.nlm.nih.gov/pubmed/11021833
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