Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons

Deposition of amyloid β-peptide (Aβ) in cerebral vessel walls (cerebral amyloid angiopathy, CAA) is very frequent in Alzheimer’s disease and occurs also as a sporadic disorder. Here, we describe significant CAA in addition to amyloid plaques, in aging APP/Ld transgenic mice overexpressing the London...

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Autores principales: Van Dorpe, Jo, Smeijers, Liesbet, Dewachter, Ilse, Nuyens, Dieter, Spittaels, Kurt, Van den Haute, Chris, Mercken, Marc, Moechars, Dieder, Laenen, Isabelle, Kuiperi, Cuno, Bruynseels, Koen, Tesseur, Ina, Loos, Ruth, Vanderstichele, Hugo, Checler, Frédéric, Sciot, Raf, Van Leuven, Fred
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2000
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850171/
https://ncbi.nlm.nih.gov/pubmed/11021833
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