Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons

Deposition of amyloid β-peptide (Aβ) in cerebral vessel walls (cerebral amyloid angiopathy, CAA) is very frequent in Alzheimer’s disease and occurs also as a sporadic disorder. Here, we describe significant CAA in addition to amyloid plaques, in aging APP/Ld transgenic mice overexpressing the London...

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Main Authors: Van Dorpe, Jo, Smeijers, Liesbet, Dewachter, Ilse, Nuyens, Dieter, Spittaels, Kurt, Van den Haute, Chris, Mercken, Marc, Moechars, Dieder, Laenen, Isabelle, Kuiperi, Cuno, Bruynseels, Koen, Tesseur, Ina, Loos, Ruth, Vanderstichele, Hugo, Checler, Frédéric, Sciot, Raf, Van Leuven, Fred
格式: Artigo
語言:Inglês
出版: American Society for Investigative Pathology 2000
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850171/
https://ncbi.nlm.nih.gov/pubmed/11021833
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