Prominent Axonopathy in the Brain and Spinal Cord of Transgenic Mice Overexpressing Four-Repeat Human tau Protein

Mutations in the human tau gene cause frontotemporal dementia and parkinsonism linked to chromosome 17. Some mutations, including mutations in intron 10, induce increased levels of the functionally normal four-repeat tau protein isoform, leading to neurodegeneration. We generated transgenic mice tha...

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Dettagli Bibliografici
Autori principali: Spittaels, Kurt, Van den Haute, Chris, Van Dorpe, Jo, Bruynseels, Koen, Vandezande, Kris, Laenen, Isabelle, Geerts, Hugo, Mercken, Marc, Sciot, Raf, Van Lommel, Alfons, Loos, Ruth, Van Leuven, Fred
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 1999
Soggetti:
Animal Models
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866931/
https://ncbi.nlm.nih.gov/pubmed/10595944
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