Prominent Axonopathy and Disruption of Axonal Transport in Transgenic Mice Expressing Human Apolipoprotein E4 in Neurons of Brain and Spinal Cord

The epsilon 4 allele of the human apolipoprotein E gene (ApoE4) constitutes an important genetic risk factor for Alzheimer’s disease. Recent experimental evidence suggests that human ApoE is expressed in neurons, in addition to being synthesized in glial cells. Moreover, brain regions in which neuro...

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Hlavní autoři: Tesseur, Ina, Van Dorpe, Jo, Bruynseels, Koen, Bronfman, Francisca, Sciot, Raf, Van Lommel, Alfons, Van Leuven, Fred
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2000
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Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885744/
https://ncbi.nlm.nih.gov/pubmed/11073810
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