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Glycoprotein Ibα forms disulfide bonds with 2 glycoprotein Ibβ subunits in the resting platelet

It is widely accepted that glycoprotein (GP) Ib contains one Ibα and one Ibβ subunit that are connected by a disulfide bond. It is unclear which Cys residue in Ibα, C484 or C485, forms the disulfide bond with Ibβ. Using mutagenesis studies in transfected Chinese hamster ovary (CHO) cells, we found t...

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Main Authors: Luo, Shi-Zhong, Mo, Xi, Afshar-Kharghan, Vahid, Srinivasan, Sankaranarayanan, López, José A., Li, Renhao
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785083/
https://ncbi.nlm.nih.gov/pubmed/17008541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-05-024091
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