A functional 14-3-3ζ–independent association of PI3-kinase with glycoprotein Ibα, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex

Engagement of the adhesion receptor glycoprotein (GP) Ib-IX-V by von Willebrand factor (VWF) mediates platelet adhesion to damaged vessels and triggers platelet activation and thrombus formation in heart attack and stroke. GPIb-IX-V contains distinct 14-3-3ζ–binding sites at the GPIbα C-terminus inv...

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Detalhes bibliográficos
Main Authors: Mu, Fi-Tjen, Andrews, Robert K., Arthur, Jane F., Munday, Adam D., Cranmer, Susan L., Jackson, Shaun P., Stomski, Frank C., Lopez, Angel F., Berndt, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2343594/
https://ncbi.nlm.nih.gov/pubmed/18299448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-111096
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