The membrane-proximal intermolecular disulfide bonds in glycoprotein Ib influence the receptor binding to von Willebrand factor

BACKGROUND: In the platelet glycoprotein (GP) Ib-IX complex, the binding site for its ligand von Willebrand factor (VWF) is restricted in the N-terminal domain of the GPIbα subunit. How the other subunits in the complex, GPIbβ and GPIX, regulate the GPIbα-VWF interaction is not clear. OBJECTIVES AND...

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Huvudupphovsmän: Mo, Xi, Luo, Shi-Zhong, Munday, Adam D., Sun, Wensheng, Berndt, Michael C., Lopez, Jose A., Dong, Jing-fei, Li, Renhao
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671080/
https://ncbi.nlm.nih.gov/pubmed/18647229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2008.03088.x
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