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The membrane-proximal intermolecular disulfide bonds in glycoprotein Ib influence the receptor binding to von Willebrand factor
BACKGROUND: In the platelet glycoprotein (GP) Ib-IX complex, the binding site for its ligand von Willebrand factor (VWF) is restricted in the N-terminal domain of the GPIbα subunit. How the other subunits in the complex, GPIbβ and GPIX, regulate the GPIbα-VWF interaction is not clear. OBJECTIVES AND...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2671080/ https://ncbi.nlm.nih.gov/pubmed/18647229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2008.03088.x |
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