טוען...
Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114
TMC114 (darunavir) is a promising clinical inhibitor of HIV-1 protease (PR) for treatment of drug resistant HIV/AIDS. We report the ultra-high 0.84Å resolution crystal structure of the TMC114 complex with PR containing the drug resistant mutation V32I (PR(V32I)), and the 1.22 Å resolution structure...
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| Main Authors: | , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2006
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1781337/ https://ncbi.nlm.nih.gov/pubmed/16962136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2006.08.007 |
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