Susceptibility of Potent Antiviral Inhibitor to Highly Drug Resistant Mutations D30N, I50V and L90M of HIV-1 Protease

The potent new antiviral inhibitor TMC-114 (UIC-94017) of HIV-1 protease (PR) has been studied with three PR variants containing single mutations D30N, I50V and L90M that provide resistance to the major clinical inhibitors. The inhibition constants (Ki) of TMC-114 for mutants PR(D30N), PR(I50V), and...

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Detalhes bibliográficos
Main Authors: Kovalevsky, Andrey Yu., Tie, Yunfeng, Liu, Fengling, Boross, Peter I., Wang, Yuan-Fang, Leshchenko, Sofiya, Ghosh, Arun K., Harrison, Robert W., Weber, Irene T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3015180/
https://ncbi.nlm.nih.gov/pubmed/16480273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm050943c
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