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Potent New Antiviral Compound Shows Similar Inhibition and Structural Interactions with Drug Resistant Mutants and Wild Type HIV-1 Protease

The potent new antiviral inhibitor GRL-98065 (1) of HIV-1 protease (PR) has been studied with PR variants containing the single mutations D30N, I50V, V82A and I84V that provide resistance to the major clinical inhibitors. Compound 1 had inhibition constants of 17-fold, 8-fold, 3-fold and 3-fold, res...

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Dettagli Bibliografici
Autori principali: Wang, Yuan-Fang, Tie, Yunfeng, Boross, Peter I., Tozser, Jozsef, Ghosh, Arun K., Harrison, Robert W., Weber, Irene T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751596/
https://ncbi.nlm.nih.gov/pubmed/17696515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm070482q
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