Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 Å resolution crystal structures of HIV-1 protease mutants with substrate analogs

HIV-1 protease (PR) and two drug-resistant variants – PR with the V82A mutation (PR(V82A)) and PR with the I84V mutation (PR(I84V)) – were studied using reduced peptide analogs of five natural cleavage sites (CA-p2, p2-NC, p6(pol)-PR, p1-p6 and NC-p1) to understand the structural and kinetic changes...

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Main Authors: Tie, Yunfeng, Boross, Peter I., Wang, Yuan-Fang, Gaddis, Laquasha, Liu, Fengling, Chen, Xianfeng, Tozser, Jozsef, Harrison, Robert W., Weber, Irene T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1360291/
https://ncbi.nlm.nih.gov/pubmed/16218957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2005.04923.x
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