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Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 Å resolution crystal structures of HIV-1 protease mutants with substrate analogs
HIV-1 protease (PR) and two drug-resistant variants – PR with the V82A mutation (PR(V82A)) and PR with the I84V mutation (PR(I84V)) – were studied using reduced peptide analogs of five natural cleavage sites (CA-p2, p2-NC, p6(pol)-PR, p1-p6 and NC-p1) to understand the structural and kinetic changes...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1360291/ https://ncbi.nlm.nih.gov/pubmed/16218957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2005.04923.x |
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