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Structural Evidence for Effectiveness of Darunavir and Two Related Antiviral Inhibitors against HIV-2 Protease
No drugs have been targeted specifically for HIV-2 infection despite the increasing prevalence worldwide. The antiviral HIV-1 protease inhibitor darunavir, and the chemically related GRL-98065 and GRL-06579A, were designed with the same chemical scaffold and different substituents at P2 and P2′ to o...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597724/ https://ncbi.nlm.nih.gov/pubmed/18834890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.09.031 |
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